As we saw in a previous article, NAD+ is a key molecule for health and longevity . Indeed, this coenzyme plays a fundamental role in various biological processes, notably in energy metabolism , DNA repair and the regulation of oxidative reactions . ( 1 )
However, there is another equally essential player in this molecular interaction : NADH . Although closely related to NAD+, NADH has characteristics and functions of its own. Understanding the difference between these two forms of Nicotinamide Adenine Dinucleotide helps us to better understand their impact on our body.
What is the relationship between NAD+ and NADH?
The relationship between NAD+ and NADH is at the heart of cellular metabolism , characterized by a dynamic balance between these two forms of the same molecule, Nicotinamide Adenine Dinucleotide .
1. Biochemical transformation
NAD+ (Oxidized Nicotinamide Adenine Dinucleotide) is transformed into NADH when it accepts electrons and a proton during biochemical reactions . This transformation is essential in metabolic processes like glycolysis (energy breakdown of glucose) and the Krebs cycle (energy production by oxidation) , where NAD+ acts as an electron acceptor , thereby converting to NADH. ( 2 )
2. Role in energy production
NADH plays a crucial role in the electron transport chain, a major step in cellular respiration that takes place in mitochondria (cells' powerhouses) . Here, NADH gives up the electrons it has acquired, helping in the production of ATP (adenosine triphosphate) , the body's main energy molecule . This transfer of electrons is vital for maintaining efficient cellular function . ( 3 )
3. Redox balance and cellular functions
The NAD+/NADH ratio is a key indicator of the redox (reduction-oxidation) state of the cell, affecting various biological processes such as cellular communication, regulation of gene expression (related to genes or genetics) , and even longevity. An imbalance in this ratio can influence cellular metabolism and is associated with several pathologies , including diabetes , heart disease and aging . ( 4 )
Is it better to choose NAD+ or NADH?
The choice between NAD+ and NADH depends on each individual's specific health goals and metabolic needs .
If you want to improve your energy metabolism or support your brain function , NADH might be better because it is directly involved in energy production . Therefore, for goals related to DNA repair , slowing aging , or improving general health , NAD+ may be more appropriate.
Caution : Call a professional to ensure you make an optimal choice.
As you will have understood, NAD+ and NADH are two sides of the same coin , constantly interacting to support cellular energy , health and overall functionality of the body . This dynamic relationship is a fascinating example of how biochemical processes regulate life at the cellular level .